Klahr, E., Trieselt, W., Trapp, H., & Widder, R. (1982). Patent No. 4,349,669. Washington, DC: . Patent and Trademark Office.
As of 2014, the only fully specific biomarkers found to date are four proteins in the CSF: CRTAC-IB ( cartilage acidic protein ), tetranectin (a plasminogen -binding protein), SPARC -like protein (a calcium binding cell signalling glycoprotein ), and autotaxin -T (a phosphodiesterase )  Nevertheless, abnormal concentrations of non-specific proteins can also help in the diagnosis, like chitinases  This list has been expanded on 2016, with three CSF proteins (Immunoglobulins) reported specific for MS. They are the following immunoglobulins : Ig γ-1 (chain C region), Ig heavy chain V-III (region BRO) and Ig-κ-chain (C region) 
Ocular rosacea may be present in varying degrees in up to 50 percent of rosacea sufferers. In an NRS survey of 1,780 rosacea patients reporting ocular symptoms, only 27 percent said they had been diagnosed with the condition, possibly indicating underdiagnosis. Typical symptoms of ocular rosacea may include a watery or bloodshot appearance, foreign body sensation, burning or stinging, itching, light sensitivity, blurred vision, and visible blood vessels or redness of the eyelid. A history of styes and feeling of dryness in the eyes are also key indicators.