Ketosteroid definition

DHEA is transformed into DHEA-S by sulfation at the C3β position via the sulfotransferase enzymes SULT2A1 and to a lesser extent SULT1E1 . [40] [50] [51] This occurs naturally in the adrenal cortex and during first-pass metabolism in the liver and intestines when exogenous DHEA is administered orally. [ citation needed ] Levels of DHEA-S in circulation are approximately 250 to 300 times those of DHEA. [19] DHEA-S in turn can be converted back into DHEA in peripheral tissues via steroid sulfatase (STS). [52] [53]

Testosterone is significantly correlated with aggression and competitive behaviour and is directly facilitated by the latter. There are two theories on the role of testosterone in aggression and competition. [78] The first one is the challenge hypothesis which states that testosterone would increase during puberty thus facilitating reproductive and competitive behaviour which would include aggression. [78] Thus it is the challenge of competition among males of the species that facilitates aggression and violence. [78] Studies conducted have found direct correlation between testosterone and dominance especially among the most violent criminals in prison who had the highest testosterone levels. [78] The same research also found fathers (those outside competitive environments) had the lowest testosterone levels compared to other males. [78]

Ketosteroid definition

ketosteroid definition


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