Nonsteroidal anti inflammatory drugs list

Meloxicam use can result in gastrointestinal toxicity and bleeding, headaches, rash, and very dark or black stool (a sign of intestinal bleeding). Like other NSAIDs , its use is associated with an increased risk of cardiovascular events such as heart attack and stroke . [5] It has fewer gastrointestinal side effects than diclofenac , [6] piroxicam , [7] naproxen , [8] and perhaps all other NSAIDs which are not COX-2 selective. [6] Although meloxicam inhibits formation of thromboxane A, it does not appear to do so at levels that would interfere with platelet function.

In the 1990s, researchers discovered that two different COX enzymes exist: COX-1 and COX-2. COX-1 is present in most tissues, including the stomach lining. It’s also involved in kidney function. COX-2 is the enzyme primarily present at sites of inflammation . Both COX-1 and COX-2 convert arachidonic acid to prostaglandin, resulting in pain and inflammation. The anti-inflammatory action of NSAIDs is mainly due to inhibition of COX-2, and their unwanted side effects (like bleeding ulcers) are largely due to inhibition of COX-1. ( 12 )

nonsteroidal anti-inflammatory drug, a drug that suppresses inflammation in a manner similar to steroids , but without the side effects of steroids; commonly referred to by the acronym NSAID (ĕn´sĕd) . Also effective in alleviating pain and fever, NSAIDs are commonly used to treat the symptoms of arthritis, gout, bursitis, painful menstruation, and headache. They act by inhibiting the synthesis of prostaglandins, leukotrienes, and other compounds that are involved in the inflammatory process.

Aspirin is technically an NSAID, but the term is often used to refer to nonaspirin products. The first nonaspirin NSAIDs were introduced in 1964. Common NSAID products include diclofenac (Cataflam, Voltaren), indomethacin (Indocin), ketorolac (Acular, Toradol), and piroxicam (Feldene). Ibuprofen , naproxen , and ketoprofen are available as over-the-counter drugs in the United States. The cox-2 inhibitors, such as celecoxib (Celebrex), selectively inhibit clooxygenase-2 (cox-2), an enzyme that causes pain and inflammation in arthritic joints, but do not interfere with cox-1, which protects the stomach and intestinal lining from ulceration. Very common drugs, NSAIDs are taken daily by an estimated 3 million Americans.

Although they are often considered easier to tolerate than aspirin, and most do not have as strong an anticlotting effect as aspirin, NSAIDS can have serious side effects, particularly gastrointestinal ulcers and upper gastrointestinal tract bleeding and perforation in those who take the drugs on a regular basis. NSAID-related gastropathy results in more than 2,000 deaths in the United States each year.

NSAIDs may reduce the benefit of drugs used for treating hypertension because NSAIDs may increase blood pressure . NSAIDs decrease the elimination of lithium ( Eskalith ) and methotrexate ( Rheumatrex ) potentially leading to their toxicity , and reduce the action of diuretics (" water pills") by reducing blood flow to the kidneys. NSAIDs increase bleeding by decreasing the activity of blood platelets and therefore formation of blood clots. When used with other drugs that also increase bleeding, for example, warfarin ( Coumadin ), the likelihood of bleeding complications is increased. Prolonged use of NSAIDs with drugs that increase bleeding should be avoided.

Andrea Leigh Zaenglein, MD  Professor of Dermatology and Pediatrics, Department of Dermatology, Hershey Medical Center, Pennsylvania State University College of Medicine

Andrea Leigh Zaenglein, MD is a member of the following medical societies: American Academy of Dermatology , Society for Pediatric Dermatology

Disclosure: Received consulting fee from Galderma for consulting; Received consulting fee from Valeant for consulting; Received consulting fee from Promius for consulting; Received consulting fee from Anacor for consulting; Received grant/research funds from Stiefel for investigator; Received grant/research funds from Astellas for investigator; Received grant/research funds from Ranbaxy for other; Received consulting fee from Ranbaxy for consulting.

Nonsteroidal anti inflammatory drugs list

nonsteroidal anti inflammatory drugs list

NSAIDs may reduce the benefit of drugs used for treating hypertension because NSAIDs may increase blood pressure . NSAIDs decrease the elimination of lithium ( Eskalith ) and methotrexate ( Rheumatrex ) potentially leading to their toxicity , and reduce the action of diuretics (" water pills") by reducing blood flow to the kidneys. NSAIDs increase bleeding by decreasing the activity of blood platelets and therefore formation of blood clots. When used with other drugs that also increase bleeding, for example, warfarin ( Coumadin ), the likelihood of bleeding complications is increased. Prolonged use of NSAIDs with drugs that increase bleeding should be avoided.

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