Treatment may include external and internal medications for itching. Aveeno oatmeal baths, anti-itch medicated lotions and steroid creams may be prescribed to combat the rash. Lukewarm, rather than hot, baths may be suggested. Strenuous activity, which could aggravate the rash, should be discouraged. Ultraviolet light treatments given under the supervision of a dermatologist may be helpful. Recently, both the antiviral drug Famvir and the antibiotic erythromycin have been claimed to produce healing in one to two weeks. For severe cases a few days of oral anti-inflammatory medications such as prednisone may be necessary to promote healing. For mild cases, no treatment is required as this disease is not a dangerous skin condition.
Some immunologic data also suggest a viral etiology. [ 6 ] A lack of natural killer (NK) cell and B-cell activity in PR lesions has been noted, suggesting a predominantly T-cell mediated immunity in the development of the condition. Increased amounts of CD4 T cells and Langerhans cells are present in the dermis, possibly reflecting viral antigen processing and presentation. Anti−immunoglobulin M (IgM) to keratinocytes has been found in patients with PR; this finding may be associated with the exanthem phase of the presumed viral infection.