The first isolation and structure identifications of prednisone and prednisolone were done in 1950 by Arthur Nobile .    The first commercially feasible synthesis of prednisone was carried out in 1955 in the laboratories of Schering Corporation, which later became Schering-Plough Corporation , by Arthur Nobile and coworkers.  They discovered that cortisone could be microbiologically oxidized to prednisone by the bacterium Corynebacterium simplex. The same process was used to prepare prednisolone from hydrocortisone . 
I have never written a review on anything really, but I thought it was important in this case. I have been dealing with arthritis for probably 15 years. I was essentially given two choices: the first is take Allopurinol and hope it prevents me from getting sprouts. However, I would have to take a 20 mg pill every day, and this medication has upset my stomach in the past. Option two is to treat an outbreak when it occurs with the medication. I went this route, and took Colchicine, which is the medication to treat this. The problem is that it never seemed to work, and I recently had a terrible gout attack. I got Prednisone and it really worked miracles. I was probably 70% better after one full day, and now almost 100% after three days. I am more than satisfied with this medication!