Credelio, a new chewable monthly flea and tick preventative from Elanco (March 2018)
Elanco Animal Health, owned by Eli Lilly and company, is the latest veterinary company to launch an isoxazoline flea product for dogs, similar to Simparica from Zoetis and Bravecto from Merck (see below). Credelio (lotilaner) is a monthly chewable tablet approved for puppies and dogs 8 weeks of age and older and pounds and greater. It protects against ticks of common concern across the ., such as the lone star tick, American dog tick, black-legged tick and brown dog tick, as well as fleas. In studies, the company reports, Credelio killed 100 percent of fleas within 12 hours for the entire month, and the product started to kill ticks and fleas in just four hours. When given with food, Credelio reaches peak blood levels within two hours of dosing, product representatives say.
Fluralaner is readily absorbed from the topical administration site into the hair, skin and subjacent tissues, from where it is slowly absorbed into the vascular system. A plateau is seen in plasma between 7 and 63 days post administration, after which conentrations decline slowly. The prolonged persistence and slow elimination from plasma (t1/2 = 21 days) and the lack of extensive metabolism provide effective concentrations of fluralaner for the duration of the inter-dosing interval. Unchanged flurarlaner is excreted in faeces and to a very low extent in urine.